A computational model is a complete description of how a neural system functions, and in that sense the ultimate specification of neuroscience theory. The models are constrained by and validated with existing experimental data, and then used to generate predictions for further biological experiments. Our work in this area focuses on understanding the visual cortex, episodic and associative memory, aphasic and dyslexic impairments of the lexical system, and language impairments in schizophrenia.