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Predicting language treatment response in bilingual aphasia using neural network-based patient models (2021)
Uli Grasemann
, Claudia Peñaloza, Maria Dekhtyar,
Risto Miikkulainen
, and
Swathi Kiran
Predicting language therapy outcomes in bilinguals with aphasia (BWA) remains challenging due to the multiple pre- and poststroke factors that determine the deficits and recovery of their two languages. Computational models that simulate language impairment and treatment outcomes in BWA can help predict therapy response and identify the optimal language for treatment. Here we used the BiLex computational model to simulate the behavioral profile of language deficits and treatment response of a retrospective sample of 13 Spanish-English BWA who received therapy in one of their languages. Specifically, we simulated their prestroke naming ability and poststroke naming impairment in each language, and their treatment response in the treated and the untreated language. BiLex predicted treatment effects accurately and robustly in the treated language and captured different degrees of cross-language generalization in the untreated language in BWA. Our cross-validation approach further demonstrated that BiLex generalizes to predict treatment response for patients whose data were not used in model training. These findings support the potential of BiLex to predict therapy outcomes for BWA and suggest that computational modeling may be helpful to guide individually tailored rehabilitation plans for this population.
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Citation:
Scientific Reports
, 11(10497):1-11, 2021.
Bibtex:
@article{grasemann:scirep21, title={Predicting language treatment response in bilingual aphasia using neural network-based patient models}, author={Uli Grasemann and Claudia Peñaloza, Maria Dekhtyar and Risto Miikkulainen and Swathi Kiran }, volume={11}, journal={Scientific Reports}, number={10497}, month={ }, pages={1-11}, url="http://nn.cs.utexas.edu/?grasemann:scirep21", year={2021} }
People
Uli Grasemann
Postdoctoral Alumni
uli [at] cs utexas edu
Swathi Kiran
Collaborator
kirans [at] bu edu
Risto Miikkulainen
Faculty
risto [at] cs utexas edu
Software/Data
BiLex
Download at GitHub
.
A self-organizing map model of bilingual aphasia. ...
2021
Areas of Interest
Natural Language Processing (Cognitive)
Cognitive Science
Brain and Cognitive Disorders
Computational Neuroscience
Unsupervised Learning, Clustering, and Self-Organization